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KMID : 0376219680050010115
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Chonnam Medical Journal
1968 Volume.5 No. 1 p.115 ~ p.122
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Testosterone Production Rate in Stein-Leventhal Syndrome
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Abstract
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A thin layer chromatographic procedure, which is able to separate testosterone from epitestosterone and testosterone metabolites, was developed. Using this new procedure, the testosterone production rate was estimated in normal males and females, and females with hirsutism.
The testosterone production rate ranged from 5.9. to 8.0, mean 6.9 mg/d in 4 normal males and 0.7 to 1.5, mean 1.0 mg/d in 3 normal females. Hirsutism with elevated 17-ketosteroid did not show any significant elevation in testosterone levels, whereas two cases of Stein-Leventhal syndrome demonstrated markedly elevated production rates with normal urinary 17-ketosteroid. In a case of Stein-Leventhal syndrome, estrogen administration markedly suppressed the: testosterone production rate, while the urinary 17-ketosteroid remained unsuppressed.
The evidences presented above indicate that the origin-of the testosterone secretion in the cases of Stein-Leventhal is the ovary.
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